Cancer Cause and Prevention Research

To identify cancer risks and risk reduction strategies, to identify factors that cause cancer in man, and to discover and develop mechanisms for cancer prevention in man.

Research programs include: (1) epidemiology; (2) chemical, physical and molecular carcinogenesis; (3) early detection biomarkers;

credit:
(4) nutrition and bioactive food components; (5) immunology and vaccines; (6) field studies and statistics; (7) chemoprevention; (8) agent development; and (9) organ site studies.

Small Business Innovation Research (SBIR) program: To expand and improve the SBIR program; to increase private sector commercialization of innovations derived from Federal research and development; to increase small business participation in Federal research and development; and to foster and encourage participation in socially and economically disadvantaged small business concerns and women-owned small business concerns in technological innovation.

Small Business Technology Transfer (STTR) program: To stimulate and foster scientific and technological innovation through cooperative research and development carried out between small business concerns and research institutions; to foster technology transfer between small business concerns and research institutions; to increase private sector commercialization of innovations derived from Federal research and development and economically disadvantage small business concerns and women-owned small business concerns in technological innovation.

Agency - Department of Health and Human Services

The Department of Health and Human Services is the Federal government's principal agency for protecting the health of all Americans and providing essential human services, especially to those who are least able to help themselves.

Office - None.

Not applicable.
Website Address

http://www.cancer.gov


Relevant Nonprofit Program Categories





Selected Recipients for this Program


RecipientAmount Start DateEnd Date
University Of Texas Medical Branch At Galveston $ 1,798,687   2008-04-182016-01-31
Rutgers, The State University Of New Jersey $ 365,789   2013-01-182015-12-31
University Of New Mexico $ 2,611,629   2010-03-012015-12-31
University Of Alabama At Birmingham $ 346,413   2013-01-022015-12-31
Fred Hutchinson Cancer Research Center $ 173,360   2013-01-012015-12-31
Vanderbilt University, The $ 2,944,730   2000-06-012015-12-31
Scripps Research Institute, The $ 1,888,528   2010-07-012015-12-31
Regents Of The University Of Michigan $ 920,530   2011-01-012015-12-31
New York University $ 218,911   2012-03-012015-12-02
Sloan-kettering Institute For Cancer Research $ 170,488   2013-01-022015-11-30



Program Accomplishments

Fiscal Year 2016: Competing FY2016 RPG actual 342 awards which were 13.3% of applications received. Competing FY2016 SBIR/STTR actual 13 awards which were 11.4% of applications received. Fiscal Year 2017: FY2017 estimated total awards to be made is 1,319. Fiscal Year 2018: FY2018 estimated total awards to be made is 1,100.

Uses and Use Restrictions

Grants and cooperative agreements may be made to eligible institutions for the support of cancer research projects.

The grants and cooperative agreements may be used for personnel, consultant costs, equipment, supplies, travel, patient costs, animals, alterations and renovations, miscellaneous items, and indirect costs.

Restrictions are imposed against the use of funds for entertainment, foreign travel (unless specifically authorized), office equipment, and other items not normally necessary for the effective prosecution of such research.

SBIR Phase I grants (of approximately 6-months' duration) are to establish the technical merit and feasibility of a proposed research effort that may lead to a commercial product or process.

Phase II grants are for the continuation of the research initiated in Phase I, and that are likely to result in commercial products or processes.

Only Phase I awardees are eligible to receive Phase II support.

STTR Phase I grants (normally of 1-year duration) are to determine the scientific, technical, and commercial merit and feasibility of the proposed cooperative effort that has potential for commercial application.

Phase II funding is based on results of research initiated in Phase I and scientific and technical merit and commercial potential of Phase II application.

The SBIR Fast-Track Initiative provides additional assistance to applicants by expediting the decision and award of SBIR Phase II funding for scientifically meritorious applications for projects that have a high potential for commercialization.

Fast-Track is a parallel review option whereby Phase I and Phase II projects are reviewed concurrently with the aim of reducing or eliminating the funding gap between Phase I and Phase II.

Eligibility Requirements

Applicant Eligibility

The awardee will be a university, college, hospital, public agency, nonprofit research institution or for-profit organization that submits an application and receives a grant or cooperative agreement for support of research by a named principal investigator.

SBIR grants can be awarded only to domestic small businesses (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed, and have no more than 500 employees).

Primary employment (more than one- half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project.

In both Phase I and Phase II, the research must be performed in the U.S.

and its possessions.

To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

STTR grants can be awarded only to domestic small business concern (entities that are independently owned and operated for profit, are not dominant in the field in which research is proposed and have no more than 500 employees) which 'partner' with a research institution in cooperative research and development.

At least 40 percent of the project is to be performed by the small business concern and at least 30 percent by the research institution.

In both Phase I and Phase II, the research must be performed in the U.S.

and its possessions.

To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

Beneficiary Eligibility

Any nonprofit or for-profit organization, company, or institution engaged in biomedical research on cancer.

Credentials/Documentation

For-profit organizations' costs are determined in accordance with 48 CFR, Subpart 31.2 of the Federal Acquisition Regulations. For other grantees, costs will be determined in accordance with HHS Regulations 45 CFR, Part 75. For SBIR and STTR grants, the applicant organization (small business concern) must present in a research plan an idea that has potential for commercialization and furnish evidence that scientific competence, experimental methods, facilities, equipment, and funds requested are appropriate to carry out the plan. Grant form SF424(R&R) (version as specified in the FOA) is used to apply for SBIR Phase I and Phase II, and STTR Phase I and Phase II. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Aplication and Award Process

Preapplication Coordination

Preapplication coordination is not applicable.

Environmental impact information is not required for this program.

This program is excluded from coverage under E.O.

12372.

Application Procedures

2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program. Depending on the grant mechanism, form PHS-398 (Rev. March 2016) or form SF424 (R&R) (version as specified as the FOA) is the standard application form. Both forms can be obtained online at http://grants.nih.gov/grants/forms.htm. SBIR and STTR Grant Solicitations and SBIR Contract Solicitations may be obtained electronically through the NIH's Small Business Funding Opportunities home page at http://www.nih.gov/grants/funding/sbir.htm. The Solicitations include submission procedures, review considerations, and grant application or contract proposal forms. All competing SBIR and STTR grant applications must be submitted electronically to the NIH via Grants.gov (http://www.grants.gov/).

Award Procedures

Grants and cooperative agreements are funded based on scientific merit, program relevance and program balance and are made annually. Initial award provides funds for the first budget period (usually 12 months) and Notice of Grant Award (Form PHS 1533-2) indicates support recommended for the remainder of the project period, allocation of Federal funds by budget categories, and special conditions, if any. All accepted SBIR/STTR applications are evaluated for scientific and technical merit by an appropriate scientific peer review panel and by a national advisory council or board. All applications receiving a priority score compete for available SBIR/STTR set-aside funds on the basis of scientific and technical merit and commercial potential of the proposed research, program relevance, and program balance among the areas of research.

Deadlines

Contact the headquarters or regional office, as appropriate, for application deadlines.

Authorization

Public Health Service Act, Sections 301, 410 and 411, Public Law 78-410, as amended, Public Law 100-607, as amended, 42 U.S.C. 241, 42 U.S.C. 285 - 285a-1; Small Business Research and Development Enhancement Act of 1992, Public Law 102-564.

Range of Approval/Disapproval Time

(Grants) Approximately 10 months. SBIR/STTR: About 7-1/2 months.

Appeals

A principal investigator (P.I.) may question the substantive or procedural aspects of the review of his/her application by communicating with the staff of the Institute. A description of the NIH Peer Review Appeal procedures is available online through the NIH home page at http://www.grants.nih.gov/grants/guide/notice-files/not97-232.html.

Renewals

Applications submitted for renewal must be reviewed and selected for funding on a competitive basis.

Assistance Considerations

Formula and Matching Requirements

This program has no statutory formula. This program has no matching requirements. MOE requirements are not applicable to this program.

Length and Time Phasing of Assistance

Grants and Cooperative Agreements: Average 3 to 4 years, maximum of 5 years. Renewals may be awarded for additional periods of up to 5 years based on competitive peer review. Funding is provided through Monthly Demand Payment System or Letter of Credit. SBIR: Normally, Phase I awards are for 6 months; normally, Phase II awards are for 2 years. STTR: Normally, Phase I awards are for 1 year; normally, Phase II awards are for 2 years. Method of awarding/releasing assistance: by letter of credit.

Post Assistance Requirements

Reports

No program reports are required.

No cash reports are required.

Progress reports are required each year.

Annual financial status report is required 90 days after end of budget period.

Special reports may be requested by DHHS.

Terminal reports are required 6 months after the end of a project.

Expenditure reports are not applicable.

Performance monitoring is not applicable.

Audits

In accordance with the provisions of 2 CFR 200, Subpart F - Audit Requirements, non-Federal entities that expend financial assistance of $750,000 or more in Federal awards will have a single or a program-specific audit conducted for that year. Non-Federal entities that expend less than $750,000 a year in Federal awards are exempt from Federal audit requirements for that year, except as noted in 2 CFR 200.503. Grants and cooperative agreements are subject to inspection and audits by DHHS and other Federal officials.

Records

Expenditures and other financial records must be retained for 3 years from the day on which the grantee submits the last financial status report for the report period.

Financial Information

Account Identification

75-0849-0-1-550 - Cancer Causation Research.

Obigations

(Project Grants (Cooperative Agreements)) FY 16 $643,076,000; FY 17 est $686,569,000; and FY 18 est $572,918,000 - Cancer Causation Research Grants FY2016 RPG act. $622,142,000, FY2016 SBIR/STTR act. $11,986,000; Other Research: $9,569,000 FY2017 RPG est. 656,894,000, FY2017 SBIR/STTR est. $13,249,000 Other Research: $16,426,000 FY2018 RPG est. $550,299,000, FY2018 SBIR/STTR est. $10,237,000 Other Research: $12,382,000.

Range and Average of Financial Assistance

Range: $30,000 to $3,863,910 Average: $473,472.

Regulations, Guidelines, and Literature

42 CFR 52; 45 CFR 75; NIH Grants Policy Statement (10/1/16); Grants will be available under the authority of and administered in accordance with the NIH Grants Policy Statement and Federal regulations at 42 CFR 52 and 42 U.S.C. 241; Omnibus Solicitation of the Public Health Service for Small Business Innovation Research (SBIR) Grant and Cooperative Agreement Applications. Omnibus Solicitation of the National Institutes of Health for Small Business Technology Transfer (STTR) Grant Applications.

Information Contacts

Regional or Local Office

None. Not applicable.

Headquarters Office

Shamala K. Srinivas 9609 Medical Center Drive Seventh Floor, West Tower, 7W530, MSC 9750, Rockville, Maryland 20850 Email: shamala@mail.nih.gov Phone: 240-276-6442 Fax: 240-276-7682

Criteria for Selecting Proposals

The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; 2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the qualifications of the proposed principal investigator, supporting staff, and consultants; (4) the technological innovation, originality, or societal importance of the proposed research; (5) the potential of the proposed research for commercial application; (6) the reasonableness of the budget requested for the work proposed; (7) the adequacy and suitability of the facilities and research environment; and (8) where applicable, the adequacy of assurances detailing the proposed means for a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment.



Social Entrepreneurship
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Yorkshire Schoolkids Bags Funding for Recycling Business


Yorkshire Schoolkids Bags Funding for Recycling Business

A team of young student entrepreneurs from Yorkshire’s St Bede’s Catholic Grammar School have scored £2,500 in cash and a £500 seed fund for Trash4Cash – their idea of a recycling business.




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